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Professor Barrie Finnin
The Professor of Formulation Science at the Victorian College of Pharmacy is Barrie Finnin.
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Currently, his specific area of research is in drug delivery through the skin, and drug uptake by the buccal mucosa.* Professor Finnin is also studying the interaction of cosmetics with the skin. How can nanotechnology be used as a vehicle for releasing active ingredients into the skin - whether they are cosmetic ingredients or drugs?
"I have a background in studying the delivery of drugs by these routes, particularly with skin and buccal mucosa delivery. The application of nanotechnology to the problem of drug delivery is an important component in our research."
There is a real impact on society with this research as far as the so called 'cosmecuetical' preparations are concerned. It is important to establish whether or not claims made by the cosmetic companies as to the efficacy of their products can be justified. In addition, can it be demonstrated that the consumer is getting real value for money?
In the process of conducting these investigations, Professor Finnin is hopeful he may discover more effective ways to deliver active cosmetic ingredients in the skin aging process and in sun protection. The skin and the buccal mucosa are real barriers to the delivery of drugs, but, by using different forms of nanotechnology, Professor Finnin aims to overcome this problem. Nanoparticles react with the skin by creating a drug reservoir which can then be used to release drugs into the skin.
Professor Finnin has collaborated widely in the course of his research. Internationally, he is working with Professor Jonathan Hadgraft at the London School of Pharmacology. In Australia, Professor Finnin conducts his commercial work with Acrux. This biomedical company is engaged in developing and commercialising a range of healthcare products for global markets. They use state of the art technology to administer drugs through the skin. He also is working closely with Dr Lewinns Cosmetics on their cosmecuetical products.
* The mucous membrane lining the inner cheek
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Professor Barrie Finnin checks the moisture levels in his skin to determine whether the anti-ageing claims made by cosmetics companies are correct.
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Selected Publications
Nicolazzo, J.A., Finnin, B.C. In vivo and in vitro models for assessing drug absorption across the buccal mucosa. (2008) Biotechnology: Pharmaceutical Aspects. Drug Absorption studies, in situ, in vitro and in silico models, 89-111.
Cilcott, R.P., Barai, N., Beezer, A.E., Brain, S.I., Brown, M.B., Bunge, A.L., Burgess, S.E., Cross, S., Dalton, C.H., Dias, A., Farinha, A., Finnin, B.C., Gallagher, S.J., Green, D.M, Gunt, H., Gwyther, R.L., Heard, C.M, Jarvis, C.A., Kamiyama, F., Kasting, G.B., Ley, E.E., Lim, S.T., Mcnaughton, G.S., Morris, A., Nazemi, M.H., Pellet, M.A., Du Plessis, J., Quan, Y.S., Raghavan, S.L., Roberts, M., Romonchuk, W., Roper, C.S., Schenk, D., Simonsen, L., Simpson, A., Traversa, B.D., Trottet, L., Watksinson, A., Wilkinson, S.C., Williams, F.M., Yamamoto, A., Hadgraft, J. Inter - and intralaboratory variation of in vitro diffusion cell measurements: An international and multicenter study using quasi-standardized methods and materials. (2005) Journal of Pharmaceutical Sciences94(3): 632-638.
Nicolazzo, J.A., Reed, B.L. and Finnin, B.C. Enhancing the buccal mucosal uptake and retention of triamcinolone acetonide. Journal of Controlled Release,105: 240-248, 2005.
Nicolazzo, J.A., Morgan, T.M., Reed, B.L. and Finnin, B.C. Synergistic enhancement of testosterone transdermal delivery. Journal of Controlled Release,103: 577-585, 2005.
Nicolazzo, J.A., Reed, B.L. and Finnin, B.C. Enhanced Buccal Mucosal Retention and Reduced Buccal Permeability of Estradiol in the presence pf Padimate O and Azone®: A Mechanistic Study. Journal of Pharmaceutical Sciences, 94(4): 873-882, 2005.
Thomas, B.J. and Finnin, B.C. The transdermal revolution. Research Focus Reviews (9): 697-703 (2004) .
Nicolazzo, J.A, Reed, B.L. and Finnin, B.C. "Modification of Buccal Drug Delivery Following pretreatment with Skin Penetration Enhancers". J. Pharm.Sci.,8: 2064-2063, 2004.
Nicolazzo, J.A, Reed, B.L. and Finnin, B.C. "An assessment of the effects of sodium dodecyl sulfate on the buccal permeability of caffeine and estradiol". J. Pharm. Sci.,93: 431-440, 2004
Wolka, Anne M., Rytting, J.H Reed, B.L., and Finnin, B.C. The Interaction of the Penetration Enhancer DDAIP with a Phospholipid Model Membrane. Int. J. Pharm.,271: 5-10, 2004
Nicolazzo, J.A, Reed B.L., and Finnin, B.C. "The effect of various in vitro conditions on the permeability characteristics of the buccal mucosa". J. Pharm. Sci.,92: 2399-2410, 2003
Finnin, B.C., Morgan, T.M. Transdermal penetration enhancers: Application, limitations and potential. J. Pharm. Sci.,88: 955, 1999.
Morgan, T.M., O'Sullivan, H.M.M., Reed, B.L. and Finnin, B.C. Transdermal delivery of estradiol in postmenopausal women with a novel topical aerosol. J. Pharm. Sci., 87: 1226. 1998.
Morgan, T.M., Reed, B.L. and Finnin B.C. Enhanced skin permeation of sex hormones with novel topical spray vehicles. J. Pharm. Sci.,,87:1213, 1998.
Tait, R.J., Bond A.M., Finnin, B.C., and Reed, B.L. Rapid scanning voltammetry under steady-state conditions in a flow-through thin layer cell with a microelectrode. Collect. Czech. Chem. Comm., 56: 92, 1991.
Charman, W.N., Lai, C.S.C., Finnin B.C., and Reed, B.L. Self association of nicotinamide in aqueous solution: Mass transport freezing point depression and partition coefficient studies. Pharm. Res.,8: 1144, 1991
Dudinski, O., Finnin, B.C., and Reed, B.L. Acceptability of thickened eye drops to human subjects. Current Therapeutics Research, 33: 322, 1983.
Patents
Chew, N.Y.K., Reed, B.L., Morgan, T.M. and Finnin, B.C. Topical delivery of anti-fungal agents. (2006)USPatent Office 7094422
Chew, N.Y.K., Reed, B.L., Morgan, T.M. and Finnin, B.C. Topical delivery of anti-alopecia agents. (2006) US Patent Office 6998138.
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